Since 2011—over 14 years ago—research has clearly shown that triple-negative breast cancer is not a single disease, but rather diverse molecular subtypes. Yet the standard of care remains largely unchanged. We don't even routinely subtype TNBC patients, despite a myriad of promising targeted treatments that work differentially across subtypes.
Patients don't want old and simplistic treatments that apply to the "mythical average patient" when in reality each patient is very unique. They don't want to be kept from accessing what is new and up-and-coming when they're running out of options. They want to be treated as the complex biological system they really are.
Natural interventions that treat the patient as a complex system don't fit the reductionist A/B testing model. Because they're not patentable for profit and rarely justify the millions required for clinical trials, they're never adequately studied and therefore dismissed as "non-evidence-based" with no way of becoming standard of care.
Using standard bioinformatics pipelines like GATK with MuTect2 and Funcotator, we generate comprehensive tumor profiling reports from full exome sequencing. Each patient receives their complete mutational catalog, clonal architecture analysis, mutational signatures, and therapeutic implications—plus six weeks of education to understand their data.
Refer a cohort of 10-15 patients and receive specialized cohort analysis at no additional cost. We'll provide gene ontology pathway analysis, identify patterns of disruption in key cellular processes, and generate publishable real-world evidence that can inform integrative approaches—without waiting years for conventional research.
Ready to provide your patients with research-grade molecular insights while generating real-world evidence for your integrative approaches?
Schedule a consultation to discuss detailed report examples, explore cohort analysis opportunities, and brainstorm the types of analyses that would best serve your practice.